A generic alternative indicated for Autoimmune Care. Promotes immune system regulation by modulating targeted cellular responses to overactive inflammatory processes.
Designed to support organ transplant success by addressing immune system overactivity to alleviate rejection risks and mitigate long-term systemic inflammation in patients effectively.
Mechanism of Action
Sirolimus inhibits the mTOR protein, which is essential for the growth and division of immune cells. By blocking this signal, it prevents the body's T-cells from attacking and rejecting a transplanted organ.
Route of Administration
Oral
Onset Time
Steady state in 1 week
Duration
Approximately 60 hours
Contraindications
Hypersensitivity to sirolimus, Severe liver impairment, Lung transplant (risk of dehiscence)
Severe Adverse Events
Severe lung toxicity, Increased cancer risk (Lymphoma), Serious infections, Kidney damage, Delayed wound healing
Common Side Effects
Acne, Mild rash
Uncommon Side Effects
Mouth sores, Anemia, High cholesterol, Joint pain, Swelling in legs, Diarrhea
Drug Interactions
Ketoconazole, Rifampin, Cyclosporine, Voriconazole, Grapefruit juice, Live vaccines
Pregnancy Safety Warnings
Contraindicated; can cause fetal harm.
Age Restrictions
Safety not established under 13 for transplant.
Storage Guidelines
Store oral solution in refrigerator; tablets at room temperature; protect from light.
Information for Rapamycin is sourced from established medical standards and updated frequently. It is provided for general reference and should be confirmed with a healthcare professional before use.
