A clinical formulation indicated for Antivirals. It assists in lowering viral replication within the blood to manage chronic viral markers effectively.
Utilized to manage chronic Hepatitis C by addressing viral replication to support liver health and mitigate the risk of cirrhosis and liver cancer progression.
Mechanism of Action
Sofosbuvir blocks the NS5B protein, which the Hepatitis C virus needs to copy its RNA. By halting this replication process, the drug effectively stops the virus from spreading and multiplying in liver cells.
Route of Administration
Oral
Onset Time
Steady state in 2 days
Duration
24 hours
Contraindications
Concurrent use with amiodarone, Severe renal impairment (some formulations), Hypersensitivity
Severe Adverse Events
Severe bradycardia (with amiodarone), Hepatitis B reactivation, Severe liver injury, Severe allergic reactions, Depression
Common Side Effects
Mild headache, Fatigue
Uncommon Side Effects
Nausea, Insomnia, Anemia, Itching, Weakness
Drug Interactions
Amiodarone, Rifampin, St. John's Wort, Carbamazepine, Phenytoin
Pregnancy Safety Warnings
Use only if benefit justifies potential risk to the fetus.
Information for Sofosbuvir is sourced from established medical standards and updated frequently. It is provided for general reference and should be confirmed with a healthcare professional before use.
